Therapeutic Plasma Exchange
Also known as TPE · Plasma Exchange · Plasmapheresis
Therapeutic Plasma Exchange (TPE) is a medical procedure that separates the plasma from the blood's cells, removes a portion of the plasma carrying inflammatory proteins and accumulated waste, and returns the cells suspended in fresh replacement fluid.
At a Glance
- Duration
- Roughly 2–3 hours per session
- Frequency
- Protocol-dependent; often a short series with periodic maintenance
- Best For
- Inflammatory burden, autoimmune patterns, cognitive and longevity-focused protocols, high-performing adults optimizing aggressively
- Session Feels Like
- Reclined and resting with a line in each arm; most members read, work, or rest through the session
In Practice
A clinical blood therapy that filters and renews the plasma your whole body runs on.
Therapeutic plasma exchange (TPE) gently separates the plasma from your blood cells, filters out a portion that carries inflammatory proteins and accumulated cellular debris, and returns your cells suspended in fresh replacement fluid. Studied for its effects on inflammation, immune regulation, and biological aging, it is a serious, medically supervised procedure, and one of the very few places in the city equipped to deliver it is Next Health Nashville.
- Removes a portion of the inflammatory, age-related plasma burden
- Studied for immune regulation and biological aging
- Among the most advanced longevity therapies in the city
- Delivered under licensed medical supervision
What It Addresses
Concerns this helps with.
- Chronic inflammation
- Autoimmune patterns
- Cognitive and neuroinflammatory concerns
- Biological-aging optimization
- Accumulated plasma burden
- Advanced longevity protocols
Before You Book
Your first visit.
A reclined session of roughly two to three hours with a line in each arm, during which a portion of your plasma is separated, filtered, and replaced with fresh fluid. You can read, work, or rest throughout, and it runs under licensed medical supervision.
Who it’s not for
It is one of the most advanced therapies offered, not an entry point. It suits people managing specific inflammatory or autoimmune patterns, or running aggressive longevity protocols on an established foundation, and only after thorough screening.
Common Questions
Common questions, answered straight.
What is therapeutic plasma exchange?
TPE draws your blood, separates the plasma from the cells, removes a portion of the plasma that carries inflammatory proteins and accumulated waste, and returns your cells suspended in fresh replacement fluid. The result is a measurable reduction in circulating inflammatory and age-associated factors. It is a medically supervised procedure, not a drip.
How is TPE different from EBOO or IV therapy?
IV therapy adds nutrients to the blood. EBOO oxygenates and ozonates a portion of it. TPE goes a step further: it physically removes and replaces a portion of the plasma itself, along with the inflammatory burden it carries. Each is a different level of intervention, and your provider recommends the right one based on your goals and biomarkers.
Who is a candidate for therapeutic plasma exchange?
TPE is an advanced therapy, not a first step. It suits members managing chronic inflammatory or autoimmune patterns, or those running aggressive longevity protocols who have already built a foundation of testing, nutrition, and basic optimization. A clinician screens thoroughly before recommending it.
Is therapeutic plasma exchange safe?
Apheresis has decades of clinical use in mainstream medicine. As with any procedure involving the blood, sterile technique, contraindication screening, and clinician oversight are essential, which is why Next Health delivers it only inside a licensed medical environment.
